Trigan mk 2
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As painkillers, they are indicated, among others, in post-traumatic and muscular pains, pains after surgery or tooth extraction, neuralgia, root syndromes, discopathy, renal and hepatic colic, cancer pain, migraine, and menstrual pain. NSAIDs are considered to be on the first rung of the analgesic ladder. ĭespite the considerable progress of pharmacotherapy and the introduction of many new drugs, NSAIDs are still widely used and occupy an important place in the broadly understood pain management strategy. On the other hand, combinations allow one to increase the therapeutic effect while reducing the risk of drug-related side effects and using lower doses of individual drugs. There are many advantages of combined pain pharmacotherapy, including, above all, the possibility of obtaining an additive or synergistic effect. The pharmacotherapy of pain is often based on the need for polytherapy. This review aims to identify which combinations of NSAIDs and spasmolytics have been developed and tested and which combinations are still under development.
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The proposed fixed-dose combinations should always be based on valid therapeutic principles and consider the combined safety profile of all active substances included in the medicinal product. It is also possible to develop a fixed-dosed combination product de novo to address a new therapeutic claim and be protected by patents so that the manufacturer can obtain exclusive rights to sell a particular FDC or a formulation thereof. Another essential aspect of the use of FDCs is the improvement of medical adherence due to the reduction in the pill burden on patients. In addition, one active ingredient may counteract adverse reactions from the other. Using the synergy or additive effect of drugs, it is possible to obtain a significant therapeutic effect and faster action with the use of smaller doses of individual drugs. The benefits of fixed-dose combination products (FDCs) are that they improve the response in people with insufficient monotherapy. This review presents the most common disease entities in which combinations of NSAIDs and spasmolytic drugs are used to reduce pain.